High Performance Liquid Chromatography (HPLC)

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Shimadzu HPLC and UHPLC systems are designed to deliver high-resolution separations, reproducible results, and intelligent automation, supporting both routine and advanced analytical workflows across industries.

Shimadzu offers two primary HPLC/UHPLC architectures to suit different laboratory needs:


Industries Served

Shimadzu HPLC/UHPLC systems are widely applied across:

  • Pharmaceutical – drug development, impurity profiling, stability testing
  • Food & Beverage – additives, contaminants, and nutritional analysis
  • Water & Environment – water quality testing, pesticide and pollutant analysis
  • Clinical & Life Sciences – metabolomics, biomarker analysis
  • Chemical & Industrial – raw material characterization and quality control

Description

Nexera Series – Modular UHPLC Systems

The Nexera Series is Shimadzu’s flagship modular platform, designed for maximum flexibility, ultra-high performance, and scalability.

  • Pressure Range: Available configurations support 44 MPa, 70 MPa, 105 MPa, and up to 130 MPa, enabling everything from conventional HPLC to high-speed UHPLC separations.
  • Modular Design: Independent selection of pumps, autosamplers, detectors, and column ovens
  • High Throughput Capability: Optimized for fast gradients and short run times
i-Series – Integrated HPLC/UHPLC Systems

The i-Series combines all core HPLC components into a compact, all-in-one system, prioritizing ease of use and automation.

  • Pressure Range: Typically 50–70 MPa, suitable for routine HPLC and moderate UHPLC applications
  • Compact Footprint: Ideal for space-constrained labs
  • Simplified Operation: Pre-configured and easy to deploy

Smart AI Features & Automation

Shimadzu integrates Analytical Intelligence across HPLC/UHPLC platforms to enhance system reliability and reduce operator workload:

  • Self-Diagnostics & Auto-Recovery – detects issues such as air bubbles, leaks, or flow inconsistencies and corrects them automatically
  • FlowPilot Technology – controlled flow ramping to extend column life and prevent pressure shocks
  • Pump & System Monitoring – continuous tracking of performance parameters
  • Autosampler Intelligence – clog detection and injection accuracy verification
  • Remote Monitoring & IoT Connectivity – enables system control and diagnostics from remote locations
  • Automated Startup/Shutdown – reduces manual intervention and improves consistency

Operational Advantages

  • Reduced Downtime through predictive maintenance and automated recovery
  • Improved Data Quality via stable flow, pressure, and temperature control
  • High Throughput with fast cycle times and automation
  • Scalable Configuration from routine QC to advanced R&D applications
  • User-Friendly Operation for both expert and non-expert users